Some Food Additives Mimic Human Hormones

New research reveals that some common food additives behave like estrogen in the body.

A discovery that two commonly used food additives are estrogenic has led scientists to suspect that many ingredients added to the food supply may be capable of altering hormones.

More than 3,000 preservatives, flavorings, colors and other ingredients are added to food in the United States, and none of them are required to undergo testing for estrogenic activity, according to the Food and Drug Administration.

“We need to be mindful of these food additives because they could be adding to the total effect of other estrogen mimicking compounds we’re coming into contact with,” said Clair Hicks, a professor of food science at the University of Kentucky and spokesperson for the Institute of Food Technologists, a nonprofit scientific group.

“The benefits of using these additives in food need to be weighed against the risks they present,” Hicks said.

In a study published in December, Italian researchers screened 1,500 food additives using computer-modeling software, a much faster and cheaper approach than testing lab rats.

The researchers first used modeling to identify 13 molecules that could hypothetically bind with an estrogen receptor, a group of molecules activated by the hormone. Like a clenched fist that fits into the palm of a hand, potentially estrogenic molecules will “fit” inside the receptor, indicating they could interact and alter hormones.

Then, the researchers exposed cells to the 13 food additives, which confirmed that two have estrogen-mimicking properties. Known as “xenoestrogens,” these substances have been linked to reproductive problems in animals and perhaps humans.

The first food additive, propyl gallate, is a preservative used to prevent fats and oils from spoiling that can be found in a range of foods including baked goods, shortening, dried meats, candy, fresh pork sausage, mayonnaise and dried milk.

The second additive, 4-hexyl resorcinol, is used to prevent shrimp, lobsters, and other shellfish from discoloring.

“Some caution should be issued for the use of these two additives,” said Pietro Cozzini, one of the researchers who conducted the study and a chemistry professor at the University of Parma in Italy.

He added that further tests on rats are necessary to determine whether these additives could harm humans.

Paul Foster, whose research focuses on the potential human health effects of endocrine disruptors, agreed. He said there is a big difference between adding estrogenic molecules to cells in a culture dish and actually seeing what happens when that dose is administered to an animal.

“There are a lot of compounds that give quite strong responses in a culture dish that really don’t produce any effects on lab rats,” said Foster, who is deputy director of the National Toxicology Program’s Center for the Evaluation of Risks to Human Reproduction, which is part of the National Institutes of Health.

The major concern, Foster said, is what happens when people are exposed to mixtures of these estrogenic compounds.

“There are examples where you can take dose levels of compounds on their own that won’t produce an effect, but when you put these compounds together, you may get something different,” he said.

However, Foster said people should keep in mind that they already ingest significant numbers of fairly potent estrogens in their diets by consuming foods like tofu and milk, so findings like these shouldn’t necessarily scare people until more research has been conducted.

“It’s clear that humans are exposed to a mixture of these estrogenic compounds,” Foster said. “But you have to try to balance out what might already be present in your diet or your lifestyle with these things that might be coming from some other sources,” such as food additives.

Systems like the one used by the Italian researchers are useful for screening potentially estrogenic additives, Foster said, adding that it’s a “good first step” towards identifying these compounds.

Of the estimated 3,000 additives used in the United States to preserve foods or improve their taste and appearance, only about 2,000 have detailed toxicological information available, according to the FDA.

“Our results are part of a bigger, more important problem, which is that there could be other additives used in foods that could have estrogenic activity,” Cozzini said.

Globally, the market for additives is expected to reach more than $33 billion by 2012. There are five main reasons that companies add compounds to food: to emulsify, to preserve, to add nutritional content, to add flavor or color and to balance alkalinity and acids.

“With some 3,000 compounds being used in food formulations there may be other additives with estrogenic properties that come to light with these types of studies,” Hicks said.

Using the traditional animal testing system, “it would be impossible to test all of the additives in a short time,” Cozzini said. “Every day we discover new molecules, and we must continue to identify new ways to study them.”

Propyl gallate is considered “Generally Recognized As Safe” (GRAS) by the FDA, a title given to food additives that don’t require approval because they have a proven track record based on either a history of use before 1958 or on published scientific evidence. Examples of other GRAS substances include salt, sugar, spices and vitamins.

The other estrogenic one, 4-hexyl resorcinol, which is used on raw shelled seafood to inhibit melanosis, or black spots, was petitioned in 1990 for GRAS status. Its status is still pending, according to Michael Herndon, an FDA press officer.

The FDA’s lack of testing for estrogenic compounds doesn’t stop at additives. In 2008, an independent advisory board said the FDA ignored critical evidence concerning another estrogenic compound, bisphenol A, a plasticizing chemical found in polycarbonate baby bottles and the linings of metal foods cans.

“What we’ve seen with the FDA’s handling of BPA is that it’s had its head in the sand,” said Renee Sharp, director of the Environmental Working Group’s California office. “If you look at its assessments, what you see is that it has consistently ignored independent science and consistently used outdated methods in its assessments.”

As concern about the cumulative impacts of these chemicals grows among the scientific community, some studies are suggesting that the effects of these compounds could extend to future generations.

For example, investigators at the National Institute of Environmental Health Sciences have found that adverse effects can be seen in both the granddaughters and grandsons of mice who were developmentally exposed to diethylstilbestrol (DES), a synthetic form of estrogen that caused reproductive problems in pregnant women and their fetuses. While DES was taken off the market in 1971, there are many other compounds that have similar, estrogenic effects.

“This study is the flagship of estrogen mimickers and why we worry about them,” said Shanna Swan, director of the University of Rochester’s Center for Reproductive Epidemiology and a leading expert on reproductive effects of environmental exposures. “The fact that these chemicals can effect future generations has been a huge lesson for the science community.”

Other research has found that low doses of these chemicals can cause significant changes in those exposed to them and their developing offspring. One recent study published in Environmental Health Perspectives found that when rats are exposed to low levels of BPA during lactation, their offspring had an increased chance of breast cancer.

As the evidence that synthetic estrogens may pose a health risk mounts, researchers are uncovering these compounds in new places.

Earlier this month, researchers in Germany found traces of an unknown estrogenic substance leaching into mineral water stored in polyethylene terephthalate (PET) bottles, a commonly used plastic for storing foods and beverages.

The study is the first to find that these containers are leaching synthetic estrogens.

“We already knew that BPA was leaching from polycarbonate baby bottles, so we decided to test bottles of mineral water to see if there was any estrogenic activity,” said Martin Wagner, a PhD student in aquatic toxicology at Johann Wolfgang Goethe University in Frankfurt.

The scientists tested 20 brands of mineral water and found that 60 percent of the samples tested positive, with estrogenic activity in plastic bottles appearing twice as high as compared to activity in water from glass bottles.

In addition, the researchers found that mud snails placed inside the bottles filled with fresh water experienced reproduction rates double of control snails, which suggests that substances from the packaging, and not the water itself, caused the reproductive change.

“The results show that these leached chemicals are important enough to change reproduction in only eight weeks,” Martin said.

Further testing is needed to identify the source of the estrogenic activity, but Wagner said the study’s significance is that it shows people are exposed to more environmental endocrine disruptors than what was previously thought.

“We’re dealing with this chemical mixture, a cocktail effect, and I would say that if you look at a single compound then you might underestimate the exposure to these environmental estrogens,” he said.

Ralph Vasami, executive director of a plastics industry group, the PET Resin Association, said ongoing research on the safety of PET for the past three decades has revealed no safety issues or reasons for concern.

“PET has been proven through considerable research to be a safe packaging material for water and other food and beverage items,” he said. “The PET industry stands on its record of safety and reliability as a packaging material.”

Swan said that the studies reinforce the need for precautionary action when dealing with these types of chemicals, such as avoiding plastic products whenever possible to decrease exposure.
“If you’re taking several hits of something, even if it’s safe at a low dose, it’s going to add up,” Swan said.


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Comforter and Comforted in an Unfolding Mystery


I never really got to know the young woman. I met her during my third-year psychiatry rotation, when our team was consulted for concerns about depression.

Privacy rules won’t allow me to use her name (where possible, I’ve gotten consent from the others involved in this story). She was terminally ill, sick not just with the disease but with all the complications of its treatment, and confined to bed in the intensive care unit.

By the time I met her she could barely speak. Her face was a vacant yellow moon, and her sparse, colorless hair sprawled tangled and sweat-soaked across her pillow.

What I did come to know of her was through her boyfriend, Josh. They had been together since middle school and had stayed together even as the rest of her life fell apart.

When her strained relationship with her parents became impossible and they were no longer in her life, Josh remained her confidant and closest friend. When she learned she was seriously ill, she and Josh filled out the paperwork required to give him her durable power of attorney.

So it was that he sat by her bed day after day, occasionally rising from his post there to perform the rudimentary maintenance that she no longer could: wiping the tears from her eyes and clearing the caked secretions around her mouth.

In her medical chart, he is referred to not as her “boyfriend,” but as “family” or even simply as “Josh,” and his presence in her record traces much of the agonizing march of her illness.

As she takes a turn for the worse: “Josh feels that [the patient] is still fighting and would like to proceed with treatment.”

As organ systems begin failing: “Family will readdress code status tomorrow.”

And finally, as supportive medical care is withdrawn: “Josh understands that [she] is dying and states that he is struggling to imagine a future without her.”

Five months later, in the dead of winter, a 25-year-old man named David was changing a flat tire on the side of the road when he was struck by a van. He landed in the I.C.U. on a ventilator, with multiple fractures. I had landed there just several days earlier in my capacity as a medical student, and I would follow him as my patient for the next several weeks.

He soon became medically stable enough to move to a general hospital floor, but he had significant behavioral problems that required a sitter to stay with him around the clock. He routinely removed his feeding tube, refused to work with therapists, would not use a bedpan. He was frustrating and difficult to work with, and he was sabotaging his own recovery.

One morning I spoke with his nurse about his progress. His feeding tube had been in place for 30 hours straight. He had begun to cooperate in physical therapy, and he was using the bedpan without complaints.

David’s mother emerged into the hallway to confirm his improvement. It seemed to her to have a lot to do with the sitter who had been assigned to him for the past couple of days.

The sitter, she said, was extremely patient. He was supportive and enthusiastic, listening to David’s stories and sharing stories of his own. He was someone David could relate to, a perfect fit for him. I nodded, encouraged, and walked into the room.

There was David, sitting up in his hospital bed, animated and joking with his sitter. The thick, tedious air that had occupied David’s room effervesced and became light, and it happened so quickly I could not catch my breath.

His sitter was Josh.

It turned out he had taken a job with the hospital after his girlfriend’s death. His story, I realized, was a kind of love story, and in some way it evoked all of our stories, whether we are doctor or patient, comforter or comforted, healer or healed. Josh reaffirmed for me what we medical professionals know but all too easily forget: the human story is not a series of illnesses and treatments that we manage, but is an unfolding mystery — a process with which we ourselves are in ongoing communion, as both witnesses and full as participants.

There, settling into our place in the story, we can see it in its wholeness and let it make us whole. We take part in its healing as it unfolds, and we are healed by its unfolding.


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A Tortured Rationale for Torture

Dick Cheney’s Torture Works! tour continues to run into reporting suggesting otherwise. On Sunday, the Washington Post published an article entitled “Detainee’s Harsh Treatment Foiled No Plots.”

The headline effectively summarized the story of the interrogation of Abu Zubaida, the C.I.A.’s “first high-value captive,” taken in March 2002 and subjected to “waterboarding and other harsh interrogation methods”:

The methods succeeded in breaking him, and the stories he told of al-Qaeda terrorism plots sent CIA officers around the globe chasing leads.

In the end, though, not a single significant plot was foiled as a result of Abu Zubaida’s tortured confessions, according to former senior government officials who closely followed the interrogations.

The article, by reporters Peter Finn and Joby Warrick, was picked up yesterday by the Post’s White House Watch blogger Dan Froomkin, who underscored its importance:

Abu Zubaida was the alpha and omega of the Bush administration’s argument for torture.

That’s why Sunday’s front-page Washington Post story . . . is such a blow to the last remaining torture apologists. . . .

Zubaida was the first detainee to be tortured at the direct instruction of the White House. Then he was President George W. Bush’s Exhibit A in defense of the “enhanced interrogation” procedures that constituted torture. And he continues to be held up as a justification for torture by its most ardent defenders.

But as author Ron Suskind reported almost three years ago — and as The Post now confirms — almost all the key assertions the Bush administration made about Zubaida were wrong.

Zubaida wasn’t a major al Qaeda figure. He wasn’t holding back critical information. His torture didn’t produce valuable intelligence — and it certainly didn’t save lives.

All the calculations the Bush White House claims to have made in its decision to abandon long-held moral and legal strictures against abusive interrogation turn out to have been profoundly flawed, not just on a moral basis but on a coldly practical one as well.

Which is not to say that elements from the former Bush administration are not fighting back. Yesterday morning, Karl Rove pointed his 33,000-plus followers on Twitter to a post at the National Review with this tweet: “Powerful rebuttal of WaPo story . . . alleging interrogation of Zubaydah foiled no plots.”

That “powerful rebuttal” was written by Marc Thiessen, the former chief speechwriter for President Bush, who argued that the Post article was part of “the Left’s assault on the CIA program” and was “rife with errors and misinformation.”

Among the article’s points that Thiessen took issue with are these:

Abu Zubaydah disclosed to the CIA during this period was that the fact that KSM was the mastermind behind the 9/11 attacks and that his code name was “Muktar” — something Zubaydah thought we already knew, but in fact we did not. Intelligence officials had been trying for months to figure out who “Muktar” was. This information provided by Zubaydah was a critical piece of the puzzle that allowed them to pursue and eventually capture KSM. This fact, in and of itself, discredits the premise of the Post story – to suggest that the capture of KSM was not information that “foiled plots” to attack America is absurd on the face of it. . . .

The Post also acknowledges that Zubaydah’s “interrogations led directly to the arrest of Jose Padilla” but dismisses Padilla as the man behind a fanciful “dirty bomb” plot and notes that Padilla was never charged in any such plot.

In addition, Thiessen said, Zubayda provided “information that helped us find and capture more of those responsible for the attacks on September the 11th, including Ramzi bin al Shibh.”

Thiessen’s rejoinder to the Post was answered by Adam Serwer, writing at the the American Prospect, who said Thiessen was repeating “already discredited claims that torture led to Zubayda disclosing valuable intelligence” and obscuring “the facts about what useful information Zubayda actually provided”:

As Jane Mayer points out in The Dark Side, Zubayda did give up Padilla and KSM’s nickname, “Mukhtar.” He did both before being tortured.

In regard Ramzi bin Al Shibh, Serwer said that:

Thiessen omits entirely the key role that an Al Jazeera journalist played in securing his capture: After interviewing bin Al Shibh and KSM in Karachi, the reporter passed on information about their location to his boss, who then passed on the information to the Emir of Qatar, who passed it on to the CIA, which led to bin Al Shibh being apprehended along with other terrorism suspects.

Serwer concludes:

The Post story is therefore accurate: torturing Zubayda produced little actionable intelligence, and none of what Thiessen claims. But as I said before, because torture cannot be defended on moral or legal terms, retroactively manufacturing successes is the only recourse.


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Yosemite in winter

Yosemite National Park may be known for its towering granite cliffs and booming waterfalls, but when temperatures drop and snow falls, the park changes personality.


Morning: Upper Yosemite Falls


Morning: Rising sun casts shadow on Yosemite Valley


Evening: Pohono Bridge over the Merced River


Evening: Yosemite Valley, from the Wawona Tunnel


Evening: An icy reflection


Evening: Trees in Stoneman Meadow against a granite wall


Evening: Setting sun lights up El Capitan


Evening: Aspen trees in Stoneman Meadow


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Nudist Hotel Planned in Germany

Clothes will be strictly forbidden on the premises of Germany’s first hotel for nudists, which will open shortly in the southwestern Black Forest region.


Nudism has always been popular in Germany.


Investors plan to set up a hotel catering exclusively to nudists in the picturesque Black Forest town of Freudenstadt, which incidentally translates as Town of Joys.

Guests will be required to remove their clothes at the entrance and must be naked at all times while on the premises, according to the strict house rules that have already been posted on the Internet.

“We hope to open as soon as possible,” Silvia Probsthain, a member of staff at the planned Hotel Rosengarten, told SPIEGEL ONLINE. “It will be the first comprehensively nudist hotel in Germany.” There are similar hotels catering for nudists in Scandinavia, Croatia and the south of France, said Probsthain.

The rules state that all guests must put towels on chairs and loungers before using them, that there be no sexual harassment and that all sexual activity in commonly accessible rooms is strictly forbidden. People who break the rules will have to put their clothes on and leave.

Freudenstadt’s tourism director Michael Krause said the contracts for the hotel hadn’t been finalized yet and that it was unclear when the project will go ahead. “I’m in two minds,” Krause told SPIEGEL ONLINE. “It’s always good if a new hotel is set up but I’d prefer a normal hotel concept.”

Nude hiking is proving increasingly popular in Germany and two villages in the central Harz mountain range plan to mark special forest hiking routes for naked ramblers. The practice is frowned on in neighboring Switzerland, however, where authorities plan to fine such behavior.


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Deutschland bekommt ein FKK-Hotel im Schwarzwald


Bisher nennt sich Freudenstadt noch „die heimliche Hauptstadt des Schwarzwalds“. Doch schon bald könnte daraus die heimliche Hauptstadt der Nackten werden: Mitten im idyllischen Schwarzwald eröffnet demnächst ein FKK-Hotel. Die Hausordnung des Hauses ist streng – und verpflichtet jeden Gast zum Nacktsein.

Früher war das „Hotel Rosengarten“ in Freudenstadt (Baden-Württemberg) ein Wanderhotel, jetzt öffnet es sich einer völlig neuen Zielgruppe: den Nackten. Ein Hotel ganz ohne die lästige Frage, was man denn anziehen soll. „Es ist ein völlig ungewöhnliches Konzept”, so Freudenstadts Tourismus-Direktor Michael Krause. Dennoch gibt er zu, dass ihm ein anderes Hotel lieber gewesen wäre.

In die Schmuddelecke möchte das Hotel nicht gestellt werden – und sorgt mit einer strengen Hausordnung vor. Das Hotel dürfen ausschließlich FKK-Anhänger betreten, die Nacktheit innerhalb der Hotelanlage ist Pflicht. Mit einem Swinger-Club hat das jedoch nichts zu tun: Jeder Gast muss sich so verhalten, dass niemand sexuell belästigt wird, sexuelle Handlungen in von anderen Gästen erreichbaren Räumen sind strikt untersagt.

Wer gegen die Hausordnung verstößt, muss sich wieder anziehen – und wird sofort des Hotels verwiesen.


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Audio “Aphrodisiac” Spurs Rare Cheetah Birth–A First



In a world first, a rare baby cheetah owes its life to a doctored recording of a recently discovered male call that triggers ovulation.

Kenya, a first-time cheetah mom, gave birth to the healthy female cub on February 18 at the San Diego Zoo’s Wild Animal Park, park officials announced earlier this month.

The cub is a direct result of research reported earlier this year describing a male vocalization called a stutter-bark.

Scientists at the park’s Conservation Research had found that male stutter-barks trigger females’ reproductive systems to start releasing eggs.

The finding was a potential boon, as cheetahs can be difficult to breed in captivity because females don’t have regular ovulation cycles.

But there was still a catch: In captivity, certain females need to mate with particular males to maintain genetic diversity among the big cats.

Vocal Competition

Traditionally, scientists have found that their “arranged marriages” for the cheetahs don’t always suit the animals’ fancies—a situation that could have been aggravated by the fact that the recorded stutter-bark was from the park’s dominant male cheetah.
If a female cheetah heard the call of the dominant—and probably more desirable—male, she might reject the male chosen for her as a good genetic match, the scientists feared.

“To compensate for this, I modified the dominant male stutter-bark call slightly using an acoustic software program,” said Matt Anderson, the lead bioacoustics researcher on the project.

The software produced a stutter-bark that sounded authentic but was totally different from the calls of any of the park’s males.

The audio manipulation not only worked, it surprised the scientists by inspiring a bit of the real thing.

“We were delighted when the stutter-barks from this ‘new’ member of the cheetah group stimulated all our males to start stutter-barking themselves,” Anderson said.

“The females heard these calls and started breeding with the males that we wanted them to breed with.”

Shortly afterward Kenya was found to be pregnant, and three months later she gave birth to a single, as-yet unnamed cub.

Since inexperienced cheetah moms often have trouble rearing a lone baby, animal care staff decided to hand-raise the newborn.

Park staff are hopeful that the success could lead to more captive cheetah births in the future.


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Coin-Size Frog Found — One of World’s Smallest



As the smallest known frog species in the world’s second largest mountain range, this new amphibian is easy to miss.

But scientists searching the Andes mountains’ upper Cosnipata Valley in southern Peru, near Cusco, spotted the coin-size creature–a member of the Noblella genus–in the leaf litter of a cloud forest between 9,925 and 10,466 feet (3,025 and 3,190 meters).

The most distinctive character of the new species,” scientists write in the February issue of the journal Copeia, “is its diminutive size.” Females grow to 0.49 inch (12.4 millimeters) at most. Males make it to only 0.44 inch (11.1 millimeters).

What’s most surprising is that the frog lives at such high elevations, said study co-author Alessandro Catenazzi, a postdoctoral researcher at the University of California, Berkeley. In general, larger animals are found at greater heights.


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